import torch import torch.nn as nn import torch.nn.functional as F from backbones import ( AgeSinusoidalEncoding, BaselineEncoder, CrossAttention, GPTBlock, GaussianRBFTimeBasis, TimeRoPE, ) from targets import CHECKUP_IDX, PAD_IDX class DeepHealth(nn.Module): def __init__( self, vocab_size: int, n_embd: int, n_head: int, n_hist_layer: int, n_tab_layer: int, n_types: int, n_cont_types: int, n_categories: int, cont_type_ids: list[int], n_value_kinds: int = 3, n_bins: int = 16, target_mode: str = "next_token", # "next_token" or "all_future" time_mode: str = "relative", # "relative" or "absolute" dist_mode: str = "exponential", # "exponential", "weibull" or "mixed" dropout: float = 0.0, ): super().__init__() if target_mode not in ["next_token", "all_future"]: raise ValueError( "target_mode must be either 'next_token' or 'all_future'") if time_mode not in ["relative", "absolute"]: raise ValueError( "time_mode must be either 'relative' or 'absolute'") if dist_mode not in ["exponential", "weibull", "mixed"]: raise ValueError( "dist_mode must be either 'exponential', 'weibull' or 'mixed'") self.token_embedding = nn.Embedding(vocab_size, n_embd, padding_idx=0) self.gender_embedding = nn.Embedding( 2, n_embd) # Assuming binary gender self.token_encoder = BaselineEncoder( n_embd=n_embd, n_head=n_head, n_types=n_types, n_cont_types=n_cont_types, n_categories=n_categories, cont_type_ids=cont_type_ids, n_value_kinds=n_value_kinds, n_bins=n_bins, n_tab_layer=n_tab_layer, dropout=dropout, ) self.cross_attention = CrossAttention( n_embd=n_embd, n_head=n_head, dropout=dropout, n_rbf_bases=16, ) self.target_mode = target_mode self.time_mode = time_mode self.dist_mode = dist_mode self.n_embd = n_embd self.vocab_size = vocab_size nn.init.normal_(self.token_embedding.weight, mean=0.0, std=0.02) nn.init.zeros_(self.token_embedding.weight[0]) nn.init.normal_(self.gender_embedding.weight, mean=0.0, std=0.02) if dist_mode == "weibull": self.rho_head = nn.Linear(n_embd, vocab_size) nn.init.zeros_(self.rho_head.weight) nn.init.constant_(self.rho_head.bias, 0.5413) if dist_mode == "mixed": self.death_idx = vocab_size - 1 self.rho_death_head = nn.Linear(n_embd, 1) nn.init.zeros_(self.rho_death_head.weight) nn.init.constant_(self.rho_death_head.bias, 0.5413) if time_mode == "absolute": self.age_encoding = AgeSinusoidalEncoding(n_embd) self.blocks = nn.ModuleList([ GPTBlock( n_embd=n_embd, n_head=n_head, use_time_rope=False, use_rbf_bias=False, mlp_dropout=dropout, ) for _ in range(n_hist_layer) ]) self.rope = None self.rbf = None elif time_mode == "relative": self.age_encoding = None self.blocks = nn.ModuleList([ GPTBlock( n_embd=n_embd, n_head=n_head, use_time_rope=True, use_rbf_bias=True, mlp_dropout=dropout, ) for _ in range(n_hist_layer) ]) self.rope = TimeRoPE(n_embd // n_head) self.rbf = GaussianRBFTimeBasis(n_bases=16, max_time_diff=40.0) self.final_ln = nn.LayerNorm(n_embd) self.risk_head = nn.Linear(n_embd, vocab_size, bias=False) self.query_token = nn.Parameter(torch.zeros(n_embd)) nn.init.normal_(self.query_token, mean=0.0, std=0.02) def _make_history_attn_mask( self, padding_mask: torch.Tensor, time_seq: torch.Tensor, dtype: torch.dtype, ) -> torch.Tensor: valid_key = padding_mask[:, None, :] # (B, 1, L) visible_by_time = time_seq[:, None, :] <= time_seq[:, :, None] valid = valid_key & visible_by_time return torch.zeros( valid.shape, device=valid.device, dtype=dtype, ).masked_fill(~valid, -1e4)[:, None, :, :] def _insert_baseline_summary( self, h_disease: torch.Tensor, event_seq: torch.Tensor, baseline_summary: torch.Tensor, ) -> torch.Tensor: checkup_mask = event_seq == CHECKUP_IDX if not checkup_mask.any(): return h_disease summary = baseline_summary.to(device=h_disease.device, dtype=h_disease.dtype) return torch.where(checkup_mask.unsqueeze(-1), summary[:, None, :], h_disease) def _baseline_cls_time( self, event_seq: torch.Tensor, time_seq: torch.Tensor, padding_mask: torch.Tensor, ) -> torch.Tensor: checkup_mask = event_seq == CHECKUP_IDX inf = torch.full_like(time_seq, float("inf")) first_checkup = torch.where(checkup_mask, time_seq, inf).min(dim=1).values has_checkup = torch.isfinite(first_checkup) fallback_time = torch.where( padding_mask, time_seq, torch.full_like(time_seq, float("-inf")), ).max(dim=1).values fallback_time = torch.where( torch.isfinite(fallback_time), fallback_time, torch.zeros_like(fallback_time), ) return torch.where(has_checkup, first_checkup, fallback_time) def _encode_other_tokens( self, other_type: torch.LongTensor, other_value: torch.Tensor, other_value_kind: torch.LongTensor, other_time: torch.Tensor, cls_time: torch.Tensor, ) -> tuple[torch.Tensor, torch.Tensor, torch.Tensor]: return self.token_encoder( other_type=other_type, other_value=other_value, other_value_kind=other_value_kind, other_time=other_time, cls_time=cls_time, ) def _forward_shared( self, event_seq: torch.LongTensor, time_seq: torch.FloatTensor, sex: torch.LongTensor, mode: str, padding_mask: torch.Tensor | None = None, t_query: torch.FloatTensor | None = None, other_type: torch.LongTensor | None = None, other_value: torch.Tensor | None = None, other_value_kind: torch.LongTensor | None = None, other_time: torch.FloatTensor | None = None, **unused_kwargs, ) -> torch.Tensor: if unused_kwargs: unknown = ", ".join(sorted(unused_kwargs)) raise TypeError(f"Unexpected DeepHealth forward arguments: {unknown}") if mode not in {"next_token", "all_future"}: raise ValueError("mode must be either 'next_token' or 'all_future'") if mode == "all_future" and t_query is None: raise ValueError("t_query is required when mode='all_future'") if ( other_type is None or other_value is None or other_value_kind is None or other_time is None ): raise ValueError( "DeepHealth expects other_type, other_value, " "other_value_kind, and other_time." ) if padding_mask is None: padding_mask = event_seq > PAD_IDX else: padding_mask = padding_mask.to(device=event_seq.device, dtype=torch.bool) h_disease = self.token_embedding(event_seq) t_disease = time_seq if other_time.shape != other_type.shape: raise ValueError( "other_time must have the same shape as other_type, got " f"{tuple(other_time.shape)} vs {tuple(other_type.shape)}" ) other_time = other_time.to(device=event_seq.device, dtype=time_seq.dtype) cls_time = self._baseline_cls_time( event_seq=event_seq, time_seq=time_seq, padding_mask=padding_mask, ) h_token, token_mask, baseline_summary = self._encode_other_tokens( other_type=other_type, other_value=other_value, other_value_kind=other_value_kind, other_time=other_time, cls_time=cls_time, ) token_time = other_time.to(device=h_token.device, dtype=time_seq.dtype) h_disease = self.cross_attention( h_disease=h_disease, t_disease=t_disease, h_token=h_token, t_token=token_time, token_mask=token_mask, ) h_disease = h_disease * padding_mask.unsqueeze(-1).to(h_disease.dtype) h_disease = self._insert_baseline_summary( h_disease=h_disease, event_seq=event_seq, baseline_summary=baseline_summary, ) h_disease = h_disease * padding_mask.unsqueeze(-1).to(h_disease.dtype) if mode == "all_future": batch_size = event_seq.size(0) query = self.query_token.view(1, 1, -1).expand(batch_size, 1, -1) h_disease = torch.cat([h_disease, query], dim=1) t_disease = torch.cat([time_seq, t_query[:, None]], dim=1) query_mask = torch.ones( batch_size, 1, dtype=torch.bool, device=event_seq.device, ) padding_mask = torch.cat([padding_mask, query_mask], dim=1) sex_emb = self.gender_embedding(sex)[:, None, :] h_disease = h_disease + sex_emb h_disease = h_disease * padding_mask.unsqueeze(-1).to(h_disease.dtype) rope_cache = None rbf_cache = None if self.time_mode == "absolute": h_disease = h_disease + self.age_encoding(t_disease) h_disease = h_disease * padding_mask.unsqueeze(-1).to(h_disease.dtype) elif self.time_mode == "relative": rope_cache = self.rope.precompute_cache(t_disease) rbf_cache = self.rbf.precompute_cache(t_disease) attn_mask = self._make_history_attn_mask( padding_mask=padding_mask, time_seq=t_disease, dtype=h_disease.dtype, ) for block in self.blocks: h_disease = block( h_disease, rope_cache=rope_cache, rbf_cache=rbf_cache, attn_mask=attn_mask, ) h_disease = h_disease * padding_mask.unsqueeze(-1).to(h_disease.dtype) h_disease = self.final_ln(h_disease) h_disease = h_disease * padding_mask.unsqueeze(-1).to(h_disease.dtype) if mode == "all_future": return h_disease[:, -1, :] return h_disease def forward_next_token(self, **kwargs) -> torch.Tensor: return self._forward_shared(mode="next_token", **kwargs) def forward_all_future(self, **kwargs) -> torch.Tensor: return self._forward_shared(mode="all_future", **kwargs) def forward(self, target_mode: str | None = None, **kwargs) -> torch.Tensor: mode = self.target_mode if target_mode is None else target_mode return self._forward_shared(mode=mode, **kwargs) def calc_risk(self, x: torch.Tensor) -> torch.Tensor: return self.risk_head(x) def calc_weibull_rho(self, x: torch.Tensor) -> torch.Tensor: if self.dist_mode != "weibull": raise RuntimeError( f"calc_weibull_rho called with dist_mode={self.dist_mode!r}" ) return F.softplus(self.rho_head(x)) + 1e-6 def calc_death_rho(self, x: torch.Tensor) -> torch.Tensor: if self.dist_mode != "mixed": raise RuntimeError( f"calc_death_rho called with dist_mode={self.dist_mode!r}" ) return F.softplus(self.rho_death_head(x)).squeeze(-1) + 1e-6